The day will start with morning prayers and special prayers for the progress and prosperity of the country.
Diwali is marked by fireworks, festive meals and exchange of sweets and gifts.
The Sindh government has declared Thursday, October 19 as a holiday for Hindus in the province.
The Hindu residents of northern Sindh are concluding arrangements for the three-day Diwali festival that will begin on Wednesday evening.
The main festival of Diwali will be held at the Sadhu Bela Temple here with similar programmes at other small temples.
A ceremony is also scheduled to be held in the Khairpur district.